[HTML][HTML] The β2-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth …
S Maudsley, KL Pierce, AM Zamah, WE Miller… - Journal of Biological …, 2000 - ASBMB
Many G protein-coupled receptors (GPCRs) activate MAP kinases by stimulating tyrosine
kinase signaling cascades. In some systems, GPCRs stimulate tyrosine phosphorylation by
inducing the" transactivation" of a receptor tyrosine kinase (RTK). The mechanisms
underlying GPCR-induced RTK transactivation have not been clearly defined. Here we
report that GPCR activation mimics growth factor-mediated stimulation of the epidermal
growth factor receptor (EGFR) with respect to many facets of RTK function. β 2-Adrenergic …
kinase signaling cascades. In some systems, GPCRs stimulate tyrosine phosphorylation by
inducing the" transactivation" of a receptor tyrosine kinase (RTK). The mechanisms
underlying GPCR-induced RTK transactivation have not been clearly defined. Here we
report that GPCR activation mimics growth factor-mediated stimulation of the epidermal
growth factor receptor (EGFR) with respect to many facets of RTK function. β 2-Adrenergic …