Mature tissue macrophages form a first line of defense to recognize and eliminate potential
pathogens; these specialized cells are capable of phagocytosis, degradation of self and
foreign materials, establishment of cell–cell interactions, and the production of inflammatory
mediators. Mature tissue macrophages express a variety of receptors, including the
scavenger receptor cystein-rich (SRCR) superfamily members. CD163 is a member of the
SRCR family class B and is expressed on most subpopulations of mature tissue …