[HTML][HTML] Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels (∗)
IB Rosenwald, R Kaspar, D Rousseau, L Gehrke… - Journal of Biological …, 1995 - ASBMB
Regulation of the cell cycle is orchestrated by cyclins and cyclin-dependent kinases. We
have demonstrated previously that overexpression of eukaryotic translation initiation factor
4E (eIF-4E) in NIH 3T3 cells growing in 10% fetal calf serum leads to highly elevated levels
of cyclin D1 protein without significant increase in cyclin D1 mRNA levels, suggesting that a
post-transcriptional mechanism is involved.(Rosenwald, IB, Lazaris-Karatzas, A.,
Sonenberg, N., and Schmidt, EV (1993) Mol. Cell. Biol. 13, 7358-7363). In the present …
have demonstrated previously that overexpression of eukaryotic translation initiation factor
4E (eIF-4E) in NIH 3T3 cells growing in 10% fetal calf serum leads to highly elevated levels
of cyclin D1 protein without significant increase in cyclin D1 mRNA levels, suggesting that a
post-transcriptional mechanism is involved.(Rosenwald, IB, Lazaris-Karatzas, A.,
Sonenberg, N., and Schmidt, EV (1993) Mol. Cell. Biol. 13, 7358-7363). In the present …