[HTML][HTML] Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by β-arrestins 1 and 2
S Ahn, H Wei, TR Garrison, RJ Lefkowitz - Journal of Biological Chemistry, 2004 - ASBMB
β-Arrestin2 not only plays essential roles in seven membrane-spanning receptor
desensitization and internalization but also functions as a signal transducer in mitogen-
activated protein kinase cascades. Here we show that the angiotensin II type 1A receptor-
mediated activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in HEK-293
cells is increased when the cellular level of β-arrestin1 is down-regulated by RNA
interference but is decreased or eliminated when the cellular level of β-arrestin2 is …
desensitization and internalization but also functions as a signal transducer in mitogen-
activated protein kinase cascades. Here we show that the angiotensin II type 1A receptor-
mediated activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in HEK-293
cells is increased when the cellular level of β-arrestin1 is down-regulated by RNA
interference but is decreased or eliminated when the cellular level of β-arrestin2 is …