[HTML][HTML] Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor: a scaffold for G protein-coupled receptor-mediated Ras …
LM Luttrell, GJ Della Rocca, T van Biesen… - Journal of Biological …, 1997 - ASBMB
In many cells, stimulation of mitogen-activated protein kinases by both receptor tyrosine
kinases and receptors that couple to pertussis toxin-sensitive heterotrimeric G proteins
proceed via convergent signaling pathways. Both signals are sensitive to inhibitors of
tyrosine protein kinases and require Ras activation via phosphotyrosine-dependent
recruitment of Ras guanine nucleotide exchange factors. Receptor tyrosine kinase
stimulation mediates ligand-induced receptor autophosphorylation, which creates the initial …
kinases and receptors that couple to pertussis toxin-sensitive heterotrimeric G proteins
proceed via convergent signaling pathways. Both signals are sensitive to inhibitors of
tyrosine protein kinases and require Ras activation via phosphotyrosine-dependent
recruitment of Ras guanine nucleotide exchange factors. Receptor tyrosine kinase
stimulation mediates ligand-induced receptor autophosphorylation, which creates the initial …