[HTML][HTML] Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light
D Filatov, S Björklund, E Johansson… - Journal of Biological …, 1996 - ASBMB
Ribonucleotide reductase is responsible for the production of deoxyribonucleotides required
for DNA synthesis and consists of two nonidentical subunits, proteins R1 and R2. Here we
show that the R1 promoter can be induced up to 3-fold, and the R2 promoter is induced up
to 10-fold by UV light in a dose-dependent manner. This was demonstrated using serum-
starved, synchronized G 0/G 1 mouse fibroblast 3T3 cells stably transformed with different
R1 and R2 promoter-luciferase reporter gene constructs. R2 promoter activation requires a …
for DNA synthesis and consists of two nonidentical subunits, proteins R1 and R2. Here we
show that the R1 promoter can be induced up to 3-fold, and the R2 promoter is induced up
to 10-fold by UV light in a dose-dependent manner. This was demonstrated using serum-
starved, synchronized G 0/G 1 mouse fibroblast 3T3 cells stably transformed with different
R1 and R2 promoter-luciferase reporter gene constructs. R2 promoter activation requires a …