[HTML][HTML] Mammalian p53R2 protein forms an active ribonucleotide reductasein vitro with the R1 protein, which is expressed both in resting cells in response to DNA …
O Guittet, P Håkansson, N Voevodskaya, S Fridd… - Journal of Biological …, 2001 - ASBMB
Recently, a homologue of the small subunit of mammalian ribonucleotide reductase (RNR)
was discovered, called p53R2. Unlike the well characterized S phase-specific RNR R2
protein, the new form was induced in response to DNA damage by the p53 protein. Because
the R2 protein is specifically degraded in late mitosis and absent in G o/G 1 cells, the
induction of the p53R2 protein may explain how resting cells can obtain
deoxyribonucleotides for DNA repair. However, no direct demonstration of RNR activity of …
was discovered, called p53R2. Unlike the well characterized S phase-specific RNR R2
protein, the new form was induced in response to DNA damage by the p53 protein. Because
the R2 protein is specifically degraded in late mitosis and absent in G o/G 1 cells, the
induction of the p53R2 protein may explain how resting cells can obtain
deoxyribonucleotides for DNA repair. However, no direct demonstration of RNR activity of …