Modulation of signalling by Sprouty: a developing story
HJ Kim, D Bar-Sagi - Nature reviews Molecular cell biology, 2004 - nature.com
HJ Kim, D Bar-Sagi
Nature reviews Molecular cell biology, 2004•nature.comSprouty proteins are evolutionarily conserved inducible inhibitors of signalling by receptor
tyrosine kinases. They have been implicated in negative-feedback interactions that impart
spatial and temporal constraints to intracellular signals. The repressive function of Sprouty
proteins targets several receptor-tyrosine-kinase-dependent signalling steps, indicating that
their activities might have broader biological consequences than was initially anticipated.
tyrosine kinases. They have been implicated in negative-feedback interactions that impart
spatial and temporal constraints to intracellular signals. The repressive function of Sprouty
proteins targets several receptor-tyrosine-kinase-dependent signalling steps, indicating that
their activities might have broader biological consequences than was initially anticipated.
Abstract
Sprouty proteins are evolutionarily conserved inducible inhibitors of signalling by receptor tyrosine kinases. They have been implicated in negative-feedback interactions that impart spatial and temporal constraints to intracellular signals. The repressive function of Sprouty proteins targets several receptor-tyrosine-kinase-dependent signalling steps, indicating that their activities might have broader biological consequences than was initially anticipated.
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