[HTML][HTML] Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis: secretion of fibroblast growth factor 23 requires O-glycosylation
K Kato, C Jeanneau, MA Tarp, A Benet-Pages… - Journal of Biological …, 2006 - ASBMB
Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is
involved in initiation of O-glycosylation, were recently identified as a cause of the rare
autosomal recessive metabolic disorder familial tumoral calcinosis (OMIM 211900). Familial
tumoral calcinosis is associated with hyperphosphatemia and massive ectopic calcifications.
Here, we demonstrate that the secretion of the phosphaturic factor fibroblast growth factor 23
(FGF23) requires O-glycosylation, and that GalNAc-T3 selectively directs O-glycosylation in …
involved in initiation of O-glycosylation, were recently identified as a cause of the rare
autosomal recessive metabolic disorder familial tumoral calcinosis (OMIM 211900). Familial
tumoral calcinosis is associated with hyperphosphatemia and massive ectopic calcifications.
Here, we demonstrate that the secretion of the phosphaturic factor fibroblast growth factor 23
(FGF23) requires O-glycosylation, and that GalNAc-T3 selectively directs O-glycosylation in …