Involvement of protein phosphatase 2A in interferon-α-2b-induced apoptosis in K562 human chronic myelogenous leukaemia cells
G Saydam, HH Aydin, F Sahin, N Selvi, G Oktem… - Leukemia research, 2003 - Elsevier
Interferon-alpha (IFN-α)-2b is known to have antiproliferative effects on hematological
malignant cells, especially chronic myelogenous leukaemia (CML). However, it can induce
cytogenetical remissions in a very small percentage of the patients. Also during interferon
therapy, resistance can emerge in the CML clones. K562 is an in vitro model cell line
transformed from a Ph positive CML patient. It can be induced to differentiate to granulocytic
and/or monocytic lineages with certain molecules. IFN-α-2b generally exerts its effects on …
malignant cells, especially chronic myelogenous leukaemia (CML). However, it can induce
cytogenetical remissions in a very small percentage of the patients. Also during interferon
therapy, resistance can emerge in the CML clones. K562 is an in vitro model cell line
transformed from a Ph positive CML patient. It can be induced to differentiate to granulocytic
and/or monocytic lineages with certain molecules. IFN-α-2b generally exerts its effects on …