[HTML][HTML] Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7α-hydroxylase (Cyp7a1) in leptin-deficient …
T Lundåsen, W Liao, B Angelin, M Rudling - Journal of Biological …, 2003 - ASBMB
Cholesterol elimination from the body involves reverse cholesterol transport from peripheral
tissues in which the elimination of high density lipoprotein (HDL) and low density lipoprotein
(LDL) cholesterol by the liver and subsequent biliary excretion as free cholesterol and bile
acids are important. In situations of peripheral fat and cholesterol accumulation, such as
obesity, these pathways may be overloaded, contributing to increased cholesterol
deposition. Leptin has an important role in obesity, suppressing food intake and increasing …
tissues in which the elimination of high density lipoprotein (HDL) and low density lipoprotein
(LDL) cholesterol by the liver and subsequent biliary excretion as free cholesterol and bile
acids are important. In situations of peripheral fat and cholesterol accumulation, such as
obesity, these pathways may be overloaded, contributing to increased cholesterol
deposition. Leptin has an important role in obesity, suppressing food intake and increasing …