Mechanisms of B-cell lymphoma pathogenesis
R Küppers - Nature Reviews Cancer, 2005 - nature.com
Nature Reviews Cancer, 2005•nature.com
Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of
B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor
(BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells
through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent
insights into the lymphomagenic role of factors supplied by the microenvironment also offer …
of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of
B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor
(BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells
through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent
insights into the lymphomagenic role of factors supplied by the microenvironment also offer …
Abstract
Chromosomal translocations involving the immunoglobulin loci are a hallmark of many types of B-cell lymphoma. Other factors, however, also have important roles in the pathogenesis of B-cell malignancies. Most B-cell lymphomas depend on the expression of a B-cell receptor (BCR) for survival, and in several B-cell malignancies antigen activation of lymphoma cells through BCR signalling seems to be an important factor for lymphoma pathogenesis. Recent insights into the lymphomagenic role of factors supplied by the microenvironment also offer new therapeutic strategies.
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