Flow cytometry for natural killer T cells: multi-parameter methods for multifunctional cells
LS Metelitsa - Clinical Immunology, 2004 - Elsevier
Vα24-Jα18 invariant natural killer T cells (iNKT) are an evolutionary conserved sub-lineage
of T cells with effector-memory phenotype that often express an NK cell surface antigen
CD161 and is characterized by reactivity to self-glycolipids and α-galactosylceramide
(αGalCer) that are presented by monomorphic HLA class-I-like molecule CD1d. Upon
antigen recognition, iNKT cells can rapidly produce multiple cytokines and chemokines and
regulate development of Th-2 and Th-1 immune responses. Potential importance of iNKT …
of T cells with effector-memory phenotype that often express an NK cell surface antigen
CD161 and is characterized by reactivity to self-glycolipids and α-galactosylceramide
(αGalCer) that are presented by monomorphic HLA class-I-like molecule CD1d. Upon
antigen recognition, iNKT cells can rapidly produce multiple cytokines and chemokines and
regulate development of Th-2 and Th-1 immune responses. Potential importance of iNKT …