[HTML][HTML] α1-syntrophin gene disruption results in the absence of neuronal-type nitric-oxide synthase at the sarcolemma but does not induce muscle degeneration
S Kameya, Y Miyagoe, I Nonaka, T Ikemoto… - Journal of Biological …, 1999 - ASBMB
α1-Syntrophin is a member of the family of dystrophin-associated proteins and is strongly
expressed in the sarcolemma and the neuromuscular junctions. All three syntrophin
isoforms have a PDZ domain that appears to participate in protein-protein interactions at the
plasma membrane. α1-Syntrophin has additionally been shown to associate with neuronal
nitric-oxide synthase (nNOS) through PDZ domains in vitro. These observations suggest that
α1-syntrophin may work as a modular adaptor protein that can link nNOS or other signaling …
expressed in the sarcolemma and the neuromuscular junctions. All three syntrophin
isoforms have a PDZ domain that appears to participate in protein-protein interactions at the
plasma membrane. α1-Syntrophin has additionally been shown to associate with neuronal
nitric-oxide synthase (nNOS) through PDZ domains in vitro. These observations suggest that
α1-syntrophin may work as a modular adaptor protein that can link nNOS or other signaling …