Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia
MP Hefferan, P Carter, M Haley, CW Loomis - Pain, 2003 - Elsevier
To determine if spinal prostaglandins (PG) contribute to tactile allodynia, male, Sprague–
Dawley rats were fitted with either intrathecal (it) microdialysis or drug delivery catheters 3
days before tight ligation of the left lumber 5/6 spinal nerves. Paw withdrawal thresholds
(PWT) were determined using von Frey filaments. Ligated rats developed tactile allodynia
within 24h, as evidenced by a decrease in PWT in the affected hindpaw (< 4g vs.> 15g
control). Sham-operated controls were unchanged from baseline (> 15g). Allodynia was also …
Dawley rats were fitted with either intrathecal (it) microdialysis or drug delivery catheters 3
days before tight ligation of the left lumber 5/6 spinal nerves. Paw withdrawal thresholds
(PWT) were determined using von Frey filaments. Ligated rats developed tactile allodynia
within 24h, as evidenced by a decrease in PWT in the affected hindpaw (< 4g vs.> 15g
control). Sham-operated controls were unchanged from baseline (> 15g). Allodynia was also …