8-Chlorodibenz [b, f][1, 4] oxazepine-10 (11H)-carboxylic acid, 2-[3-[2-(furanylmethyl) thio]-1-oxopropyl] hydrazide (SC-51322): a potent PGE2 antagonist and …
EA Hallinan, A Stapelfeld, MA Savage… - Bioorganic & Medicinal …, 1994 - Elsevier
EA Hallinan, A Stapelfeld, MA Savage, M Reichman
Bioorganic & Medicinal Chemistry Letters, 1994•ElsevierE. Ann Hallinan,* Awilda Stapelfeld, Michael A. Savage, Melvin Reichman Department of
Chemistry Searle 4901 Searle Parkway Skoki Page 1 Prim&d in Grut Britain. AU righ mad o%o-894m
s4.mw 0960-894X(93)EOllS-H E. Ann Hallinan,* Awilda Stapelfeld, Michael A. Savage, Melvin
Reichman Department of Chemistry Searle 4901 Searle Parkway Skokie, Illinois 60077
SC-51322 is the most potent PGEa antagonist (PAZ = 8.1) and analgesic @Wo = 0.9 mgkg)
that has been seen in this series of N-subetituted dibenxoxaxepines. Prostaglandin E2 (PGE2) …
Chemistry Searle 4901 Searle Parkway Skoki Page 1 Prim&d in Grut Britain. AU righ mad o%o-894m
s4.mw 0960-894X(93)EOllS-H E. Ann Hallinan,* Awilda Stapelfeld, Michael A. Savage, Melvin
Reichman Department of Chemistry Searle 4901 Searle Parkway Skokie, Illinois 60077
SC-51322 is the most potent PGEa antagonist (PAZ = 8.1) and analgesic @Wo = 0.9 mgkg)
that has been seen in this series of N-subetituted dibenxoxaxepines. Prostaglandin E2 (PGE2) …
Abstract
SC-51322 is the most potent PGE2 antagonist (pA2 = 8.1) and analgesic (ED50 = 0.9 mg/kg) that has been seen in this series of N-substituted dibenzoxazepines.
Elsevier