[HTML][HTML] Interorganelle trafficking of ceramide is regulated by phosphorylation-dependent cooperativity between the PH and START domains of CERT
K Kumagai, M Kawano, F Shinkai-Ouchi… - Journal of Biological …, 2007 - ASBMB
The synthesis and transport of lipids are essential events for membrane biogenesis.
However, little is known about how intracellular trafficking of lipids is regulated. Ceramide is
synthesized at the endoplasmic reticulum (ER) and transported by the ceramide transfer
protein CERT to the Golgi apparatus, where it is converted to sphingomyelin. CERT has a
phosphoinositide-binding pleckstrin homology (PH) domain for Golgi-targeting and a lipid
transfer START domain for intermembrane transfer of ceramide. We here show that CERT …
However, little is known about how intracellular trafficking of lipids is regulated. Ceramide is
synthesized at the endoplasmic reticulum (ER) and transported by the ceramide transfer
protein CERT to the Golgi apparatus, where it is converted to sphingomyelin. CERT has a
phosphoinositide-binding pleckstrin homology (PH) domain for Golgi-targeting and a lipid
transfer START domain for intermembrane transfer of ceramide. We here show that CERT …