Definition and risks of cytokine release syndrome in 11 critically ill COVID-19 patients with pneumonia: analysis of disease characteristics
W Wang, X Liu, S Wu, S Chen, Y Li… - The Journal of …, 2020 - academic.oup.com
W Wang, X Liu, S Wu, S Chen, Y Li, L Nong, P Lie, L Huang, L Cheng, Y Lin, J He
The Journal of Infectious Diseases, 2020•academic.oup.comAbstract Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities
are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of
symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a
single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome
from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January
2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight …
are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of
symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a
single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome
from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January
2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight …
Abstract
Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of symptoms of CRS in critically ill patients with COVID-19 are important problems. We report a single-center case series of 11 COVID-19 patients with acute respiratory distress syndrome from The First Affiliated Hospital of Guangzhou Medical University in China from 26 January 2020 to 18 February 2020. The termination date of follow-up was 19 February 2020. Eight patients were determined to have characteristics of CRS, including pulmonary inflammation, fever, and dysfunction of nonpulmonary organs. An increase in interleukin-6 in peripheral blood was the highest risk factor and an early indicator of CRS in COVID-19.
Oxford University Press