Levels of the TNF related cytokine, LIGHT increase in hospitalized COVID-19 patients with Cytokine Release Syndrome and ARDS (preprint)
DS Perlin, I Zafir-Lavie, L Roadcap, S Raines, CF Ware… - 2020 - pesquisa.bvsalud.org
Many COVID-19 patients demonstrate lethal respiratory complications caused by cytokine
release syndrome (CRS). Multiple cytokines have been implicated in CRS, but TNFSF14
(LIGHT) has not been previously measured in this setting. In this study, we observed
significantly elevated serum LIGHT levels in hospitalized COVID-19 patients as compared to
healthy age and gender matched control patients. The assay detected bioavailable LIGHT
unbound to the inhibitor Decoy receptor-3 (DcR3). Bioavailable LIGHT levels were elevated …
release syndrome (CRS). Multiple cytokines have been implicated in CRS, but TNFSF14
(LIGHT) has not been previously measured in this setting. In this study, we observed
significantly elevated serum LIGHT levels in hospitalized COVID-19 patients as compared to
healthy age and gender matched control patients. The assay detected bioavailable LIGHT
unbound to the inhibitor Decoy receptor-3 (DcR3). Bioavailable LIGHT levels were elevated …
[PDF][PDF] Levels of the TNF-related cytokine LIGHT increase in hospitalized COVID-19 patients with cytokine release syndrome and ARDS. mSphere. 5: e00699-20
DS Perlin, I Zafir-Lavie, L Roadcap, S Raines, CF Ware… - 2020 - academia.edu
ABSTRACT Many coronavirus disease 2019 (COVID-19) patients demonstrate lethal
respiratory complications caused by cytokine release syndrome (CRS). Multiple cytokines
have been implicated in CRS, but levels of tumor necrosis factor superfamily 14
(TNFSF14)(LIGHT) have not been previously measured in this setting. In this study, we
observed significantly elevated serum LIGHT levels in hospitalized COVID-19 patients
compared to healthy age-and gender-matched control patients. The assay detected …
respiratory complications caused by cytokine release syndrome (CRS). Multiple cytokines
have been implicated in CRS, but levels of tumor necrosis factor superfamily 14
(TNFSF14)(LIGHT) have not been previously measured in this setting. In this study, we
observed significantly elevated serum LIGHT levels in hospitalized COVID-19 patients
compared to healthy age-and gender-matched control patients. The assay detected …
