The yellow coloration of the macula lutea is attributable to the presence of macular pigment in the axons of its photoreceptors. 1 In the 1980s several investigators demonstrated that macular pigment consists of the xanthophyll isomers, lutein and zeaxanthin. 2 3 Although the role of the macular pigment remains uncertain, several functions have been hypothesised and these include reduction of the eVects of light scatter and chromatic aberration on visual performance, 4 5 limitation of the damaging photo-oxidative eVects of blue light through its absorption, 6–8 and protection against the adverse eVects of photochemical reactions because of the antioxidant properties of the carotenoids. 9 10

Age related macular degeneration (AMD) is the leading cause of visual loss in people over the age of 65 years in the Western world. 11 Although the aetiopathogenesis of AMD remains a matter of debate, there is a growing body of evidence to indicate that oxidative damage plays a role. 12–14 Consequently, the possibility that the absorption characteristics and antioxidant properties of macular pigment confer protection against AMD has been postulated. 10 15 A proved protective eVect of macular pigment may be of therapeutic value, as it has recently been reported that human macular pigment can be augmented with dietary modification. 16