Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
JA Smith, A Das, SK Ray, NL Banik - Brain research bulletin, 2012 - Elsevier
Microglia are activated in response to a number of different pathological states within the
CNS including injury, ischemia, and infection. Microglial activation results in their production
of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. While release of these factors is
typically intended to prevent further damage to CNS tissue, they may also be toxic to
neurons and other glial cells. Mounting evidence indicates that chronic microglial activation
may also contribute to the development and progression of neurodegenerative disorders …
CNS including injury, ischemia, and infection. Microglial activation results in their production
of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. While release of these factors is
typically intended to prevent further damage to CNS tissue, they may also be toxic to
neurons and other glial cells. Mounting evidence indicates that chronic microglial activation
may also contribute to the development and progression of neurodegenerative disorders …