[HTML][HTML] New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients
PH Papotto, S Maeda, J Tomimori… - PLoS Neglected …, 2015 - journals.plos.org
PLoS Neglected Tropical Diseases, 2015•journals.plos.org
Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern
balance. Given the increasing epidemiological overlay of HIV and M. leprae infections,
immune response in co-infected patients consists in an important contemporary issue. Here
we describe for the first time the innate lymphoid cells compartment in peripheral blood of
leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2
innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
balance. Given the increasing epidemiological overlay of HIV and M. leprae infections,
immune response in co-infected patients consists in an important contemporary issue. Here
we describe for the first time the innate lymphoid cells compartment in peripheral blood of
leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2
innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
Abstract
Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
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