Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies
T Suda, R Masuyama, R Bouillon… - Current Opinion in …, 2015 - Elsevier
Highlights•The physiological role of vitamin D depends on calcium supply and calcium
balance.•When the calcium balance is normal, the major target of vitamin D is
intestine.•Vitamin D stimulates mainly active intestinal calcium transport mechanism.•During
a negative calcium balance, bone effects of vitamin D become dominant.•The role of vitamin
D in maintaining normocalcemia has priority over skeletal integrity.The physiological role of
vitamin D depends on calcium supply and calcium balance. When the calcium balance is …
balance.•When the calcium balance is normal, the major target of vitamin D is
intestine.•Vitamin D stimulates mainly active intestinal calcium transport mechanism.•During
a negative calcium balance, bone effects of vitamin D become dominant.•The role of vitamin
D in maintaining normocalcemia has priority over skeletal integrity.The physiological role of
vitamin D depends on calcium supply and calcium balance. When the calcium balance is …