Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade
of activated transcription factors and epigenetic modifications that drive gene transcription
responsible for unique cell fate. Within the mesenchymal lineage, factors such as RUNX2
and PPARγ are indispensable for osteogenesis and adipogenesis, respectively. We
therefore investigated genomic binding of transcription factors and accompanying
epigenetic modifications that occur during osteogenic and adipogenic differentiation of …