[HTML][HTML] The RUNX2 cistrome in osteoblasts: characterization, down-regulation following differentiation, and relationship to gene expression
MB Meyer, NA Benkusky, JW Pike - Journal of Biological Chemistry, 2014 - ASBMB
RUNX2 is a transcription factor that is first expressed in early osteoblast-lineage cells and
represents a primary determinant of osteoblastogenesis. While numerous target genes are
regulated by RUNX2, little is known of sites on the genome occupied by RUNX2 or of the
gene networks that are controlled by these sites. To explore this, we conducted a genome-
wide analysis of the RUNX2 cistrome in both pre-osteoblastic MC3T3-E1 cells (POB) and
their mature osteoblast progeny (OB), characterized the two cistromes and assessed their …
represents a primary determinant of osteoblastogenesis. While numerous target genes are
regulated by RUNX2, little is known of sites on the genome occupied by RUNX2 or of the
gene networks that are controlled by these sites. To explore this, we conducted a genome-
wide analysis of the RUNX2 cistrome in both pre-osteoblastic MC3T3-E1 cells (POB) and
their mature osteoblast progeny (OB), characterized the two cistromes and assessed their …