Genomic determinants of vitamin D-regulated gene expression
JW Pike, MB Meyer, NA Benkusky, SM Lee, HS John… - Vitamins & …, 2016 - Elsevier
Insight into mechanisms that link the actions of 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3)
to the regulation of gene expression has evolved extensively since the initial discovery of a
nuclear protein known as the vitamin D receptor (VDR). Perhaps most important was the
molecular cloning of this receptor which enabled its inclusion within the nuclear receptor
gene family and further studies of both its structure and regulatory function. Current studies
are now refocused on the vitamin D hormone's action at the genome, where VDR together …
to the regulation of gene expression has evolved extensively since the initial discovery of a
nuclear protein known as the vitamin D receptor (VDR). Perhaps most important was the
molecular cloning of this receptor which enabled its inclusion within the nuclear receptor
gene family and further studies of both its structure and regulatory function. Current studies
are now refocused on the vitamin D hormone's action at the genome, where VDR together …