1α, 25-Dihydroxycholecalciferol receptors in intestine: I. association of 1α, 25-dihydroxycholecalciferol with intestinal mucosa chromatin
PF Brumbaugh, MR Haussler - Journal of Biological Chemistry, 1974 - ASBMB
Vitamin D 3 (cholecalciferol) is known to be metabolized to 1α, 25-dihydroxycholecalciferol,
and this sterol is thought to be the active form of the vitamin. The present report shows that
administration of increasing amounts of radioactive vitamin D 3 to vitamin D-deficient chicks
results in a saturable binding of 1α, 25-dihydroxycholecalciferol to the intestinal chromatin
that parallels saturation of the calcium absorption response. The appearance of 1α, 25-
dihydroxycholecalciferol in the chromatin precedes the calcium absorption response by 2 to …
and this sterol is thought to be the active form of the vitamin. The present report shows that
administration of increasing amounts of radioactive vitamin D 3 to vitamin D-deficient chicks
results in a saturable binding of 1α, 25-dihydroxycholecalciferol to the intestinal chromatin
that parallels saturation of the calcium absorption response. The appearance of 1α, 25-
dihydroxycholecalciferol in the chromatin precedes the calcium absorption response by 2 to …