Identification of 1,25-Dihydroxycholecalciferol, a Form of Vitamin D3 Metabolically Active in the Intestine
MF Holick, HK Schnoes… - Proceedings of the …, 1971 - National Acad Sciences
MF Holick, HK Schnoes, HF DeLuca
Proceedings of the National Academy of Sciences, 1971•National Acad SciencesA biologically active vitamin D3 metabolite (“peak V metabolite”) more polar than 25-
hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono
(trimethylsilyl) ether derivative. The molecule has been identified as 1, 25-
dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption
spectrophotometry, and specific chemical reactions.
hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono
(trimethylsilyl) ether derivative. The molecule has been identified as 1, 25-
dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption
spectrophotometry, and specific chemical reactions.
A biologically active vitamin D3 metabolite (“peak V metabolite”) more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions.
National Acad Sciences