Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
M Heverin, S Meaney, D Lütjohann, U Diczfalusy… - Journal of lipid …, 2005 - ASBMB
Side chain oxidizedoxysterols have a unique ability to traverse lipophilic membranes. We
tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto
the brain using plasma samples collected from the internal jugular vein andan artery of
healthy male volunteers. Two independent studies were performed, onein which total levels
of 27-hydroxycholesterol were measured and one in which thefree fraction of 27-
hydroxycholesterol was measured. In the majority of subjectsstudied, the level of 27 …
tested thehypothesis that there is a net flux of 27-hydroxycholesterol from the circulationinto
the brain using plasma samples collected from the internal jugular vein andan artery of
healthy male volunteers. Two independent studies were performed, onein which total levels
of 27-hydroxycholesterol were measured and one in which thefree fraction of 27-
hydroxycholesterol was measured. In the majority of subjectsstudied, the level of 27 …
