Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-β
YQ Xiao, K Malcolm, GS Worthen, S Gardai… - Journal of Biological …, 2002 - ASBMB
Phagocytosis of apoptotic cells by macrophages results in the production of transforming
growth factor-β (TGF-β), which plays an important role in induction of an anti-inflammatory
phenotype and resolution of inflammation. In this study, we show that TGF-β prevents pro-
inflammatory cytokine production through inhibition of p38 mitogen-activated protein kinase
(MAPK) and NF-κB. Blockade of extracellular signal-regulated kinase (ERK) signaling by the
MEK-1/2 inhibitor PD 98059 reversed the inhibitory effects of TGF-β, suggesting that cross …
growth factor-β (TGF-β), which plays an important role in induction of an anti-inflammatory
phenotype and resolution of inflammation. In this study, we show that TGF-β prevents pro-
inflammatory cytokine production through inhibition of p38 mitogen-activated protein kinase
(MAPK) and NF-κB. Blockade of extracellular signal-regulated kinase (ERK) signaling by the
MEK-1/2 inhibitor PD 98059 reversed the inhibitory effects of TGF-β, suggesting that cross …
