Effect of angiotensin-converting enzyme inhibition on glomerular basement membrane permeability and distribution of zonula occludens-1 in MWF rats
D Macconi, M Ghilardi, ME Bonassi… - Journal of the …, 2000 - journals.lww.com
The mechanism (s) by which angiotensin-converting enzyme (ACE) inhibitors prevent
glomerular membrane loss of permselective function is still not understood. In male MWF
rats, which develop spontaneous proteinuria with age, ACE inhibitors prevent proteinuria
and increase glomerular ultrafiltration coefficient. These renoprotective effects are not
associated with ultrastructural changes of capillary wall components. This study was
undertaken to investigate whether ACE inhibitors modulate functional properties of …
glomerular membrane loss of permselective function is still not understood. In male MWF
rats, which develop spontaneous proteinuria with age, ACE inhibitors prevent proteinuria
and increase glomerular ultrafiltration coefficient. These renoprotective effects are not
associated with ultrastructural changes of capillary wall components. This study was
undertaken to investigate whether ACE inhibitors modulate functional properties of …