Exploring type I angiotensin (AT1) receptor functions through gene targeting
SD Crowley, PL Tharaux, LP Audoly… - Acta physiologica …, 2004 - Wiley Online Library
SD Crowley, PL Tharaux, LP Audoly, TM Coffman
Acta physiologica scandinavica, 2004•Wiley Online LibraryThe renin–angiotensin system (RAS) modulates a diverse set of physiological processes
including development, blood pressure, renal function and inflammation. The principal
effector molecule of this system, angiotensin II, mediates most of these actions. The
classically recognized functions of the RAS are triggered via the type 1 (AT1) class of
angiotensin receptors. Pharmacological blockade of the AT1 receptor lowers blood pressure
and slows the progression of cardiovascular and renal diseases. Gene‐targeting technology …
including development, blood pressure, renal function and inflammation. The principal
effector molecule of this system, angiotensin II, mediates most of these actions. The
classically recognized functions of the RAS are triggered via the type 1 (AT1) class of
angiotensin receptors. Pharmacological blockade of the AT1 receptor lowers blood pressure
and slows the progression of cardiovascular and renal diseases. Gene‐targeting technology …
Abstract
The renin–angiotensin system (RAS) modulates a diverse set of physiological processes including development, blood pressure, renal function and inflammation. The principal effector molecule of this system, angiotensin II, mediates most of these actions. The classically recognized functions of the RAS are triggered via the type 1 (AT1) class of angiotensin receptors. Pharmacological blockade of the AT1 receptor lowers blood pressure and slows the progression of cardiovascular and renal diseases. Gene‐targeting technology provides an experimental approach for precisely dissecting the physiological functions of the RAS. Here, we review how gene‐targeting experiments have elucidated AT1 receptor functions.
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