Neuronal nitric oxide synthase: its role and regulation in macula densa cells
G Kovács, P Komlósi, A Fuson… - Journal of the …, 2003 - journals.lww.com
Macula densa (MD) cells detect changes in distal tubular sodium chloride concentration
([NaCl] L), at least in part, through an apical Na: 2Cl: K co-transporter. This co-transporter
may be a site for regulation of tubuloglomerular feedback (TGF), and recently angiotensin II
(Ang II) was shown to regulate the MD Na: 2Cl: K co-transporter. In addition, nitric oxide (NO)
produced via neuronal NO synthase (nNOS) in MD cells attenuates MD-TGF signaling. This
study investigated [NaCl] L-dependent MD-NO production, the regulation of co-transporter …
([NaCl] L), at least in part, through an apical Na: 2Cl: K co-transporter. This co-transporter
may be a site for regulation of tubuloglomerular feedback (TGF), and recently angiotensin II
(Ang II) was shown to regulate the MD Na: 2Cl: K co-transporter. In addition, nitric oxide (NO)
produced via neuronal NO synthase (nNOS) in MD cells attenuates MD-TGF signaling. This
study investigated [NaCl] L-dependent MD-NO production, the regulation of co-transporter …