Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor–deficient mice
A Ichihara, F Suzuki, T Nakagawa… - Journal of the …, 2006 - journals.lww.com
Blockade of the renin-angiotensin system slows the progression of diabetic nephropathy but
fails to abolish the development of end-stage nephropathy of diabetes. The prorenin-to-
active renin ratio significantly increases in diabetes, and prorenin binding to its receptor in
diabetic animal kidney induces the nephropathy without its conventional proteolytic
activation, suggesting that angiotensin II (AngII) may not be the decisive factor causing the
nephropathy. For identification of an AngII-independent mechanism, diabetes was induced …
fails to abolish the development of end-stage nephropathy of diabetes. The prorenin-to-
active renin ratio significantly increases in diabetes, and prorenin binding to its receptor in
diabetic animal kidney induces the nephropathy without its conventional proteolytic
activation, suggesting that angiotensin II (AngII) may not be the decisive factor causing the
nephropathy. For identification of an AngII-independent mechanism, diabetes was induced …