Glomerular involvement in adults with sickle cell hemoglobinopathies: Prevalence and clinical correlates of progressive renal failure
A Guasch, J Navarrete, K Nass… - Journal of the American …, 2006 - journals.lww.com
Patients with sickle cell anemia (SCA) may develop a glomerulopathy with proteinuria and
progressive renal insufficiency, leading to ESRD. Albuminuria is a sensitive marker of
glomerular damage in this population and precedes the development of renal insufficiency.
For determination of the prevalence of glomerular damage in SCA and the clinical correlates
of renal insufficiency, 300 adult patients with SCA were studied (hemoglobin SS= 184; and
116 with other sickling hemoglobinopathies: SC, SD, and S-β thalassemia); albumin …
progressive renal insufficiency, leading to ESRD. Albuminuria is a sensitive marker of
glomerular damage in this population and precedes the development of renal insufficiency.
For determination of the prevalence of glomerular damage in SCA and the clinical correlates
of renal insufficiency, 300 adult patients with SCA were studied (hemoglobin SS= 184; and
116 with other sickling hemoglobinopathies: SC, SD, and S-β thalassemia); albumin …