[HTML][HTML] Activation of the rat renin promoter by HOXD10· PBX1b· PREP1, Ets-1, and the intracellular domain of Notch
L Pan, ST Glenn, CA Jones, KW Gross - Journal of Biological Chemistry, 2005 - ASBMB
Renin gene expression is subject to complex developmental and tissue-specific regulation.
A comparison of the promoter sequences of the human, rat, and mouse renin genes has
revealed a highly conserved sequence homologous to the DNA recognition sequence for
CBF1 (CSL/RBP-Jκ/Su (H)/LAG1/RBPSUH). Electrophoretic mobility shift assays document
that As4. 1 cell nuclear protein complex binding to the putative rat renin CBF1-binding site (-
175 to-168 bp) contains CBF1. Transient transfection analyses in COS-7 cells further …
A comparison of the promoter sequences of the human, rat, and mouse renin genes has
revealed a highly conserved sequence homologous to the DNA recognition sequence for
CBF1 (CSL/RBP-Jκ/Su (H)/LAG1/RBPSUH). Electrophoretic mobility shift assays document
that As4. 1 cell nuclear protein complex binding to the putative rat renin CBF1-binding site (-
175 to-168 bp) contains CBF1. Transient transfection analyses in COS-7 cells further …