The human intersectin genes and their spliced variants are differentially expressed
C Pucharcos, C Casas, M Nadal, X Estivill… - … et Biophysica Acta (BBA …, 2001 - Elsevier
Human intersectins (ITSN1 and ITSN2) are members of a conserved family of proteins
involved in clathrin-mediated endocytosis. A short and a long isoform with different protein
domain compositions have been described for both human intersectins. Here, we have
resolved the exon/intron structure of the ITSN2 gene to explain the genomic origin of its
alternatively spliced transcripts. Comparison of the two ITSN human genes shows a high
level of conservation in their genomic organization, including the main alternative splicing …
involved in clathrin-mediated endocytosis. A short and a long isoform with different protein
domain compositions have been described for both human intersectins. Here, we have
resolved the exon/intron structure of the ITSN2 gene to explain the genomic origin of its
alternatively spliced transcripts. Comparison of the two ITSN human genes shows a high
level of conservation in their genomic organization, including the main alternative splicing …
