[HTML][HTML] Tumor necrosis factor-α induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K
R Sundararajan, A Cuconati, D Nelson… - Journal of Biological …, 2001 - ASBMB
Tumor necrosis factor (TNF)-α-mediated death signaling induces oligomerization of
proapoptotic Bcl-2 family member Bax into a high molecular mass protein complex in
mitochondrial membranes. Bax complex formation is associated with the release of
cytochrome c, which propagates death signaling by acting as a cofactor for caspase-9
activation. The adenovirus Bcl-2 homologue E1B 19K blocks TNF-α-mediated apoptosis by
preventing cytochromec release, caspase-9 activation, and apoptosis of virus-infected cells …
proapoptotic Bcl-2 family member Bax into a high molecular mass protein complex in
mitochondrial membranes. Bax complex formation is associated with the release of
cytochrome c, which propagates death signaling by acting as a cofactor for caspase-9
activation. The adenovirus Bcl-2 homologue E1B 19K blocks TNF-α-mediated apoptosis by
preventing cytochromec release, caspase-9 activation, and apoptosis of virus-infected cells …
