Transforming Potential of Human c-sis Nucleotide Sequences Encoding Platelet-Derived Growth Factor
SF Josephs, L Ratner, MF Clarke, EH Westin, MS Reitz… - Science, 1984 - science.org
SF Josephs, L Ratner, MF Clarke, EH Westin, MS Reitz, F Wong-Staal
Science, 1984•science.orgThe nucleotide sequence of a transforming human c-sis complementary DNA shows an
open reading frame 723 base pairs in length located downstream from an in-phase
terminator thymine-guanine-adenine codon. Sequences within this region were identical to
those previously determined for the exons of the normal human c-sis gene. Thus, the
predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for
normal human platelet-derived growth factor chain A.
open reading frame 723 base pairs in length located downstream from an in-phase
terminator thymine-guanine-adenine codon. Sequences within this region were identical to
those previously determined for the exons of the normal human c-sis gene. Thus, the
predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for
normal human platelet-derived growth factor chain A.
The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.
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