Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity
Y Xu, YX Tao - Neuroreport, 2004 - journals.lww.com
Abstract Platelet-activating factor (PAF), a bioactive phospholipid implicated in neuronal
excitotoxic death, augments the presynaptic release of glutamate. Excessive activation of
postsynaptic glutamate receptors and subsequent downstream signals leads to
excitotoxicity. The present study proposed that the NMDA receptor/nitric oxide (NO) signal
pathway might be involved in PAF-induced neurotoxicity. After the cultured neurons were
exposed to PAF for 24 h the percentage of neuronal death increased in a dose-dependent …
excitotoxic death, augments the presynaptic release of glutamate. Excessive activation of
postsynaptic glutamate receptors and subsequent downstream signals leads to
excitotoxicity. The present study proposed that the NMDA receptor/nitric oxide (NO) signal
pathway might be involved in PAF-induced neurotoxicity. After the cultured neurons were
exposed to PAF for 24 h the percentage of neuronal death increased in a dose-dependent …
