[HTML][HTML] Platelet-activating factor receptor activation: an initiator step in HIV-1 neuropathogenesis
SW Perry, JA Hamilton, LW Tjoelker, G Dbaibo… - Journal of Biological …, 1998 - ASBMB
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system results
in neuronal apoptosis. Activated HIV-1-infected monocytes secrete high levels of the
proinflammatory cytokine tumor necrosis factor-α (TNF-α) and the phospholipid mediator
platelet-activating factor (PAF). TNF-α and PAF are elevated in the central nervous system of
patients with HIV-1-associated dementia. We now demonstrate that conditioned media from
activated HIV-1-infected monocytes induces neuronal apoptosis, which can be prevented by …
in neuronal apoptosis. Activated HIV-1-infected monocytes secrete high levels of the
proinflammatory cytokine tumor necrosis factor-α (TNF-α) and the phospholipid mediator
platelet-activating factor (PAF). TNF-α and PAF are elevated in the central nervous system of
patients with HIV-1-associated dementia. We now demonstrate that conditioned media from
activated HIV-1-infected monocytes induces neuronal apoptosis, which can be prevented by …
