Effectiveness and safety of prenatal phenobarbital for the prevention of neonatal jaundice
T Valaes, K Kipouros, S Petmezaki, M Solman… - Pediatric …, 1980 - nature.com
T Valaes, K Kipouros, S Petmezaki, M Solman, SA Doxiadis
Pediatric research, 1980•nature.comThe effect of 100 mg of phenobarbital (PB) at bedtime for the last few wk of pregnancy on the
incidence and severity of neonatal hyperbilirubinemia was studied. No effect was observed
in the newborns of mothers who took less than ten tablets. In the 1310 newborns of
adequately treated mothers (PB≥ 1.0 g), the incidence of marked jaundice (bilirubin> 16.0
mg/dl) and the need to perform an exchange transfusion were reduced by a factor of six in
relation to the incidence in 1553 control infants.
incidence and severity of neonatal hyperbilirubinemia was studied. No effect was observed
in the newborns of mothers who took less than ten tablets. In the 1310 newborns of
adequately treated mothers (PB≥ 1.0 g), the incidence of marked jaundice (bilirubin> 16.0
mg/dl) and the need to perform an exchange transfusion were reduced by a factor of six in
relation to the incidence in 1553 control infants.
Abstract
The effect of 100 mg of phenobarbital (PB) at bedtime for the last few wk of pregnancy on the incidence and severity of neonatal hyperbilirubinemia was studied. No effect was observed in the newborns of mothers who took less than ten tablets. In the 1310 newborns of adequately treated mothers (PB≥ 1.0 g), the incidence of marked jaundice (bilirubin> 16.0 mg/dl) and the need to perform an exchange transfusion were reduced by a factor of six in relation to the incidence in 1553 control infants.
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