Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice
T Wüstefeld, T Rakemann, S Kubicka, MP Manns… - Hepatology, 2000 - Elsevier
Abstract Interleukin 6 (IL-6) is an important mediator of hepatocyte proliferation after
hepatectomy. However, elevated IL-6 levels are found in patients with chronic liver disease.
Therefore, it is unclear if hyperstimulation with IL-6 may have an influence on liver
regeneration. We investigated whether a strong activation of IL-6–dependent pathways may
change the course of hepatocyte proliferation after hepatectomy. Transgenic mice
overexpressing the human soluble IL-6 receptor/gp80 (hsgp80) in hepatocytes were …
hepatectomy. However, elevated IL-6 levels are found in patients with chronic liver disease.
Therefore, it is unclear if hyperstimulation with IL-6 may have an influence on liver
regeneration. We investigated whether a strong activation of IL-6–dependent pathways may
change the course of hepatocyte proliferation after hepatectomy. Transgenic mice
overexpressing the human soluble IL-6 receptor/gp80 (hsgp80) in hepatocytes were …
